Pharmacotechnical and biological characterization of a cream formulation based on aqueous extract of the trunk bark of Parkia biglobosa Jacq. (Fabaceae-Mimosoideae) intended for the treatment of inflammation

Résumé

Parkia biglobosa is a plant widely used in traditional medicine to treat pathologies with an inflammatory component. This study aimed to formulate, characterize, and determine the efficacy of a cream based on an aqueous extract of Parkia biglobosa trunk bark. Different proportions of extract were used in the formulations to identify the most effective formulation and also the impact of the extract on the preparations. Shea butter was used in the fat phase and Tween 60 / Span 60 was used as a surfactant. Direct emulsification is the technique used to prepare O/W emulsions. The creams obtained were subjected to quality control tests (macroscopic characteristics, pH, viscosity, microscopy) and efficacy tests. The tracer was detected by thin-layer chromatography. The creams were homogeneous and brown. The pH of the preparations containing the extract varied between 7.02 and 7.2. Viscosity was a function of the proportion of extract in the preparations. The 3% cream therefore had the highest viscosity at 29.414 mPas. Microscopy revealed the particle size of the preparation. Research into the tracer revealed the presence of flavonoids. The antioxidant activity by inhibiting the ABTS radical and lipid peroxidation enabled the anti-inflammatory mechanism of action of the cream based on Parkia biglobosa trunk bark to be identified. Cream made from Parkia biglobosa trunk bark powder could be an alternative to the suppository form.

Keywords: Pharmacotechnical, Antioxidant activity, Cream, Parkia biglobosa, Inflammations.